Role of secretome mesenchymal stem cells as immunomodulator in periodontal diseases

Objective: The purpose of this review literature is to look at the mechanism mesenchymal stem cell secretome in regeneration periodontal tissue.Methods: This was collected from several journals and research that has been done, where application Mesenchymal cells (MSCs) promises a favourable result for cell-based therapy inflammatory diseases, immune system disorders, regeneration, tissue repair.Results: MSCs possess potent immunomodulatory function, paracrine effects, ability differentiate into different cells. Not only can replace damaged or but also secrete namely bioactive ingredients such as cytokines, chemokines, growth factors, pro-inflammatory, anti-inflammatory which play an essential role regulating host system. Periodontal disease occurs teeth supporting structures. Lately, many therapies utilized gingival ligaments. Secretome activates endogenous improve might create better microenvironment tissue.Conclusion: attracted lot attention potential repair regenerate tissues including